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Systematic review and meta-analysis

This trial is included in the following systematic reviews and meta-analyses:

cardiovascular prevention - antioxydants - all type of patients


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SUVIMAX, 2005 - combination vs placebo

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PPP, 2001 - vitamin E vs control

AREDS, 2001 - vitamin E vs placebo

ASAP, 2000 - vitamin E vs placebo

HOPE, 2000 - vitamin E vs placebo

GISSI, 1999 - vitamin E vs control

NSCP (Green) beta carotene, 1999 - beta carotene vs placebo

WHS beta carotene, 1999 - beta carotene vs placebo

MVP, 1997 - combination vs placebo

PHS beta carotene, 1996 - beta carotene vs placebo

CARET beta carotene, 1996 - beta carotene vs placebo

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See also:

  • All cardiovascular prevention clinical trials
  • All clinical trials of antioxydants
  • All clinical trials of beta carotene
    		•  

    NSCP (Green) beta carotene study, 1999

    download pdf: beta carotene | antioxydants for cardiovascular prevention

    Treatments

    Studied treatment beta carotene 30mg four times daily
    Control treatment placebo
    Remarks factorial design of sunscreen and betacarotene

    Patients

    Patients residents of Nambour
    Baseline characteristics
    Women (%) 56% 
    age (yr) 48y 
    Body mass index NA 

    Method and design

    Randomized effectives 820 / 801 (studied vs. control)
    Design Factorial plan
    Blinding double-blind
    Follow-up duration 4.5 y
    Number of centre community study
    Geographic area Queensland, Australia
    Hypothesis Superiority
    Primary endpoint skin cancer


    Results

    Endpoint Studied treat.
    n/N     Control treat.
    n/N     Graph RR [95% CI]

    Cardiovascular death

    6 / 820
         12 / 801
         0,49 [0,18;1,30]

    All cause death

    11 / 820
         21 / 801
         0,51 [0,25;1,05]     0 2 1.0

    Relative risks
    Endpoint Events (%) Relative Risk 95% CI Endpoint definition
    in the trial    		 Ref
    Studied treat. Control treat.
    Cardiovascular death 6 / 820 (0,7%) 12 / 801 (1,5%) 0,49 [0,18;1,30]   2945
    All cause death 11 / 820 (1,3%) 21 / 801 (2,6%) 0,51 [0,25;1,05]   2945
    The primary endpoint (if exists) appears in blod characters
    Reference(s) used for data extraction:
  • 2945: Green A, Williams G, Neale R, Hart V, Leslie D, Parsons P, Marks GC, Gaffney P, Battistutta D, Frost C, Lang C, Russell ADaily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomised controlled trial.Lancet 1999 Aug 28;354:723-9
  • 0:

    • Endpoint studied treat. control treat. mean diff

    Absolute risk reduction
    Endpoint Events rate Absolute risk
    reduction (ARR)
    Studied treat. Control treat.
    Cardiovascular death 7,32‰ 1,50% -7,7‰
    All cause death 1,34% 2,62% -12,8‰

    Meta-analysis of all similar trials:

    antioxydants in cardiovascular prevention for all type of patients



    Reference(s)

    Trials register # NA
    • Green A, Williams G, Neale R, Hart V, Leslie D, Parsons P, Marks GC, Gaffney P, Battistutta D, Frost C, Lang C, Russell A. Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomised controlled trial.. Lancet 1999 Aug 28;354:723-9
      Pubmed | Hubmed | Fulltext

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