PHS II beta carotene trial

7641 men from the PHS agreed to participate in the PHSII and, beginning in August 1997, were randomized to PHSII study treatments. Treatment assignment to beta carotene or placebo was retained from the PHS (although participants may have stopped taking beta carotene during the 18-month interval between studies), and the men were newly randomized to receive vitamin E, ascorbic acid, multivitamin, or placebo.

Reference(s)

Trials register #

NCT00270647

Christen WG, Gaziano JM, Hennekens CH. Design of Physicians' Health Study II--a randomized trial of beta-carotene, vitamins E and C, and multivitamins, in prevention of cancer, cardiovascular disease, and eye disease, and review of results of completed trials.. Ann Epidemiol 2000;10:125-34

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Grodstein F, Kang JH, Glynn RJ, Cook NR, Gaziano JM. A randomized trial of beta carotene supplementation and cognitive function in men: the Physicians' Health Study II.. Arch Intern Med 2007;167:2184-90

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Sesso HD, Buring JE, Christen WG, Kurth T, Belanger C, MacFadyen J, Bubes V, Manson JE, Glynn RJ, Gaziano JM. Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial.. JAMA 2008;300:2123-33

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PHS II beta carotene study, 2003

Treatments

Patients

Method and design

Remarks / Comments

Results

Reference(s)